What Causes Spindle Cell Sarcoma?

Before understanding cancer cells and what causes spindle cell sarcoma, a brief knowledge about the normal cell cycle is important to know. Cells normally divide and for daughter cells. In this manner, the dying old cells are replaced by new younger cells.

Humans and other organisms grow and mature by increasing the number of cells in a certain part, while maintaining and/or reducing the number of cells in a specific part of the body. This is the reason why organisms do not look like a single ball (as everything started from a single rounded cell) and instead everything has a definite shape.

Formation of Cancer Cells

Basically, the formation of tumor is due to the disruption of the normal life cycle of a cell. The transformation of a normal cell into a cancer cell is due to damage in the DNA. There is what you call oncogenes and suppressor genes in the DNA.

Oncogenes promote mitotic division, while suppressor genes reduce the rate of mitotic division and encourage cell death. If there is an alteration in the balance of the two (such as downgrading the suppressor genes), cancer cells will be formed.

What is Spindle Cell Sarcoma?

A sarcoma is a type of cancer which is derived from the connective tissues which surround the visceral organs and as well as the bone tissues. Therefore, a spindle cell sarcoma is a cancer of the connective tissue that contains spindle-shaped cells. This is a rare type of cancer that is found among humans and animals.

What Causes Spindle Cell Sarcoma?

The said cancer contains spindle-shaped cells, so what causes spindle cell sarcoma? They are believed to originate in the connective tissue or in the muscles just beneath the skin. However, some researchers suggest that they may also arise from the walls of the blood vessels, since they contain smooth muscle cells which are spindle in shape.

Therefore, spindle cell sarcoma may arise everywhere in the body because blood vessels are widely distributed all over the body. This is the reason why there are many types of spindle cell sarcoma depending on its location.

As said in the previous paragraph, damaged to the DNA of a normal cell may cause it to mutate and become a cancer cell. The mutations may be due to environmental factors such as:

  • Pollution
  • Alcohol
  • Drugs
  • Excessive radiation (when treating other cancers)

Other researchers propose that when someone has an injury, the body produces spindle cells in order to heal that certain wound area. The oncogenes and suppressor genes must control the production and reduction of the cells so as not to produce continuously rapid multiplying cancer cells.

Again, if there is alteration in these genes, abnormal cancer cells will be formed. Another observation of a researcher is that after the healing process, the pancreas produces pancreatic enzymes that digest the excessive healer cells (rapidly dividing cells) in the area. If the pancreas doesn’t secrete this important enzyme, those rapidly dividing healer cells may cause the formation of tumor in the area.

So if you ask again, what causes of spindle cell sarcoma? Actually, there are no certainties for the causes of spindle cell sarcoma. These are just observations of various researchers (which may be the true cause) and they use these to aid in treating the cancer.