Pancreatic Spindle Cell Sarcoma

Cell cycle normally happens regularly and independently depending on the cell type. For example, epithelial tissues proliferate faster compared to other tissues. On the other hand, nerve cells and skeletal muscle cells don’t proliferate.

When a nerve cell dies, it is already lost forever. The other neurons will not divide again in order to replace the missing cell. This is also true for skeletal muscle cells. But for skeletal muscle cells, it is replaced by smooth muscle cells.

Cancer Cells

There are various theories on the formation of cancer cells. One of the most famous is the mutation theory. The theory states that cells that are genetically damaged, specifically the oncogenes and suppressor genes, can mutate and become cancer cells. Another theory says that injury and inflammation may lead to the formation of cancer cells.

Whenever there is an injury in the body, spindle cells start to migrate towards the wound site. These spindle cells help in the healing process of the damaged area. After the healing period, the spindle cells must stop dividing. But, if it continues to proliferate, it will form a tumor.

Spindle Cell Sarcoma of the Pancreas

Sarcoma is a type of cancer which is related to connective tissues. It has two types: these are the soft tissue sarcoma and bone sarcoma. The spindle cell sarcoma pancreas is a kind of soft tissue sarcoma that is formed by spindle cells and is found in the pancreas.

Before, there was a related disease to spindle cell sarcoma of the pancreas. It is the sarcomatoid carcinoma. It is a type of cancer that arises in the epithelium of the pancreas. But, it is made up of spindle cells, instead of epithelial cells.

At first, researchers thought that the sarcomatoid carcinoma or spindle cell carcinoma originates in the epithelium of the pancreas. But, in recent studies, they notice that it arises between the epithelium and the mesenchyme. It means that the sarcomatoid carcinoma or spindle cell carcinoma is also the spindle cell sarcoma of the pancreas.

The term sarcomatoid carcinoma of the pancreas is just the same as spindle cell sarcoma of the pancreas or carcinosarcoma. The cancer starts between the epithelium and the mesenchyme and it was made up of spindle cells.

Today, the World Health Organization groups this type of cancer under the undifferentiated carcinoma. It is because they are composed of spindle cells instead of the normal epithelial cells or mixed (epithelial cells and spindle cells).

Treatment for Spindle Cell Sarcoma of Pancreas

There are various treatments for spindle cell sarcoma. Surgery is the most famous kind of treatment because it has the lowest chance of cancer recurrence. But, its negative side is that it involves a wide range of healthy tissues because surgery in just the confines of the tumor may cause the recurrence of the cancer.

Another disadvantage of surgical removal is when it is near an important organ such as the heart and the lungs. The doctors cannot perform this technique as it may affect the function of the adjacent organ. Chemotherapy and radiotherapy are the next treatment options if surgery is not possible.